Xudong Miao
Zhejiang University, China
Title: A Novel Minimal Invasive Ablation of Pedicatric Osteosarcoma with Nanosecond Pulsed Electric Field (nsPEF) as a Palliative Therapy
Biography
Biography: Xudong Miao
Abstract
Our previous studies suggest that nanosecond pulsed electric field (nsPEF) is a novel minimal invasive and non-thermal ablation method that can induce apoptosis in.osteosarcoma MG-63 cells in vitro. The current study investigates the local and systemic antitumor efficacy of nsPEF on osteosarcoma in vivo with micro metastasis. Osteosarcomas were treated by nsPEF with puncture electrode at 40 Kv/cm electric field strength of 500 pulses. The survival time, tumor volume, serum alkaline phosphatase, joint capsule and lung metastasis were followed up to 6 months post nsPEF treatment. The efficacy was compared with no-treatment control and amputation surgery. nsPEF reduced tumor volume compared to the control group (P<0.05), it also inhibit serum alkaline phosphatase and lung metastasis, prolonged the survival time without joint deformity or capsule rupture. nsPEF cannot eradicate the tumor as amputation surgery (P<0.05), but the complication and hospitalization time were lower. Local nsPEF ablation was found to be effective in achieving longer survival and less lung metastasis without chemotherapy, radiotherapy or biological therapy. As a non-thermal ablation method, nsPEF has potential to treat osteosarcoma as a palliative therapy for osteosarcoma patients who constricted for surgery.